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1. 100mg of ritonavir along with 600mg or 4 capsules of amprenavir; twice a day; or
2. 200mg of ritonavir (2 caps) along with 1,200mg (8 caps) of amprenavir; once a day.

Common side effects associated with amprenavir include diarrhea, nausea, vomiting, numbness around the mouth, rashes, and stomach pains. A small population of the patients taking in amprenavir suffers from serious skin reactions, such as the Stevens-Johnson syndrome or other allergic reactions to the medication. Doctors prescribe over-the-counter medications to control some of these side effects.

People with allergic reaction to sulfa drugs might want to refrain from using amprenavir or seek the advice of a doctor or physician if you plan to proceed with the treatment. Considering that that amprenavir is a protease inhibitor, there were no records of it having problems with people suffering from high-cholesterol levels unlike other drugs in the same family.

Liquid-based amprevanir contains glycol that may cause some problems with infants under 4 years old, people suffering from kidney or liver problems, pregnant women, or those under specific medications.

There is a possibility for amprenavir to react with other medications or herbal supplements. Both drugs in the system might trigger an overdose that could prove fatal to the patient or an underdose that will render the treatment useless.

In most cases, other ARV drugs are said to interact adversely with amprenavir. Patients currently treated with tuberculosis drugs should avoid using the said medication. Drugs to treat headaches and migraines, as well as those used for erectile dysfunctions and control heart rhythms should be avoided when being treated with amprenavir or vice versa.

As with other protease inhibitors, patients who are planning a treatment using amprenavir must consult their doctor for a thorough physical and medical examination to avoid risks, as well as following the prescribed dosage to avoid contraindications and fatal reactions.

Agenerase

What is Agenerase (amprenavir)?

Amprenavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Amprenavir is not a cure for HIV or AIDS.

Amprenavir may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Agenerase (amprenavir)?

Do not take amprenavir with cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or an ergot medicine such as Ergomar, Cafergot, Wigraine, D.H.E. 45, Migranal, Methergine, and others. These drugs can cause life-threatening side effects if you use them while you are taking amprenavir. Amprenavir oral liquid should also not be taken with disulfiram (Antabuse) or metronidazole (Flagyl).

There are many other medicines that can interact with amprenavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

Taking amprenavir will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.

What should I discuss with my healthcare provider before taking Agenerase (amprenavir)?

Do not take this medication if you are allergic to amprenavir or a similar drug called fosamprenavir (Lexiva). Do not take amprenavir oral liquid if you are pregnant or if you have liver or kidney disease.

Do not take amprenavir with cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs can cause life-threatening side effects if you use them while you are taking amprenavir. Amprenavir oral liquid should also not be taken with disulfiram (Antabuse), metronidazole (Flagyl).

Before taking amprenavir, tell your doctor if you are allergic to any drugs, or if you have:

• liver or kidney disease;

• diabetes;

• a bleeding disorder such as hemophilia; or

• high cholesterol or triglycerides.

If you have any of these conditions, you may not be able to use amprenavir, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. HIV can be passed to the baby if the mother is not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection while you are pregnant. Taking amprenavir together with birth control pills can make the amprenavir less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking amprenavir. You should not breast-feed while you are using amprenavir. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk. Do not give this medication to a child younger than 4 years old。

How should I take Agenerase (amprenavir)?

Take amprenavir exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take amprenavir with a full glass (8 ounces) of water.

Amprenavir can be taken with or without food. Avoid taking with a high-fat meal, which can make it harder for your body to absorb the amprenavir.

Measure the liquid form of amprenavir with a special dose-measuring spoon or cup, not a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not switch from amprenavir capsules to oral liquid without your doctor's advice. Make sure you receive the right form of this medicine each time you get your prescription filled.

It is important to use amprenavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Store amprenavir at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember and take your next dose at the regularly scheduled time. If you are more than 4 hours late in taking your amprenavir, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medication, or if a child has accidentally swallowed it. An overdose of amprenavir oral liquid could be fatal to a child.

What should I avoid while taking Agenerase (amprenavir)?

Avoid drinking alcohol while using amprenavir oral liquid, and do not take disulfiram (Antabuse) or you could have an alcohol reaction.